The Filtration Rate, Effective Renal Blood Flow, Tubular Excretory Mass and Phenol Red Clearance in Specific Toxemia of Preganancy.
نویسندگان
چکیده
The vascular and renal disorders of the last trimester of pregnancy are classified by the University Obstetrical Service in the following groups: specific toxemia, pre-existing essential hypertension, pre-existing glomerulonephritis and specific toxemia superimposed on pre-existing hypertension or nephritis (1). Specific toxemia is clinically characterized by the rather abrupt appearance of hypertension, usually in the last trimester of a previously normal pregnancy. This rise in blood pressure is typically accompanied by edema and proteinuria. Hematuria and azotemia are not seen, but the convulsions of eclampsia may occur. The postpartum course of the disease likewise helps to identify it. Edema subsides soon after delivery. Proteinuria usually disappears in the puerperium, although traces of protein in the urine may be present for weeks. Blood pressure falls to a normal level in the majority soon after delivery, but it is a striking feature of such an attack that in many instances it is followed by permanent hypertension. The present communication is an investigation of renal function in specific toxemia of pregnancy, based upon a study of inulin, phenol red and diodrast clearances and diodrast Tm. The inulin clearance is considered to be a measure of the rate of glomerular filtration, diodrast clearance a measure of effective renal blood flbw and diodrast Tm a measure of tubular excretory mass (2, 3), within the definitions and limitations accorded to these terms by Smith (4). Using these methods, Goldring et al. (5, 6, 7, 8) have demonstrated that renal ischemia of varying degree, associated with an increase in filtration fraction which is indicative of efferent arteriolar
منابع مشابه
The Filtration Rate, Effective Renal Blood Flow, Tubular Excretory Mass and Phenol Red Clearance in Normal Pregnancy.
متن کامل
The Effect of Pregnancy on Renal Function in Women
The effect of pregnancy on the renal function of patients with essential hypertension or chronic glomerulonephritis has been the object of the investigation to be reported here. The study has involved the application of renal clearance methods to a group of patients, during their pregnancies and repeatedly during the 1 to 4 years after their delivery. In 3 patients, the series of records includ...
متن کاملDetermination of renal handling of marbofloxacin in Lohi sheep (Ovis aries) following a single intravenous administration
The objective of present study was to investigate renal clearance, urinary excretion and underlying excretory mechanism of marbofloxacin in Lohi sheep. For this purpose, marbofloxacin was administered intravenously (IV) as single bolus dose (2.5 mg/kg body weight) to eight healthy sheep of Lohi breed. After start of experiment, blood and urine samples were drawn at predetermined time intervals ...
متن کاملThe Control of Renal Blood Flow and Glomerular Filtration in Normal Man.
This report is concerned with the effective renal blood flow and rate of glomerular filtration in normal man, as determined by the diodrast and inulin clearances (26) during diuresis and during the action of phlorizin, adrenin, caffeine, nitrite, and typhoid vaccine. The observations not only throw light on the action of these agents, but also afford information concerning the physiological con...
متن کاملThe Effect of Pregnancy on Renal Function in Women with Pre-existing Essential Hypertension and with Chronic Diffuse Glomerulonephritis.
The effect of pregnancy on the renal function of patients with essential hypertension or chronic glomerulonephritis has been the object of the investigation to be reported here. The study has involved the application of renal clearance methods to a group of patients, during their pregnancies and repeatedly during the 1 to 4 years after their delivery. In 3 patients, the series of records includ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Journal of clinical investigation
دوره 21 1 شماره
صفحات -
تاریخ انتشار 1942